Wireless Biodevices and Systems

Conjunt de materials associats a l'assignatura Wireles Biodevices and System

Family environmental factors in at-risk mental states for psychosis

Altres ajuts: Acord transformatiu CRUE-CSICThe family environment represents an important psychosocial factor that impacts psychosis prognosis, but little is known about its effect on the at-risk stages of psychosis. This study presents a comprehensive review and summarizes the state of the art of study on the wide range of family factors related to family functioning in the At-Risk Mental State (ARMS) for psychosis, as well as family interventions in ARMS individuals. Publications were retrieved by an extensive search on MEDLINE, PsycINFO and SCOPUS (1990-2020). Expressed Emotion is the most studied variable in ARMS literature, but there is scarce evidence of the role of other significant family factors at the ARMS stage. Overall, high Expressed Emotion did not appear to be reactive to ARMS patients' poor clinical status. However, initial evidence has suggested that relatives' beliefs about the disorder may play a significant role, either as mediators of these relationships or as predictors of Expressed Emotion. Available literature yet to yield a consistent pattern of findings on the association between Expressed Emotion or other family functioning indicators and negative outcomes, but some longitudinal studies highlight the greater potential for the protective effects of positive family environments at the ARMS stage. Family-based interventions have demonstrated benefits for both ARMS individuals and family dynamics. An increased focus on the impact of the at-risk stage of illness on relatives' mental well-being is required to provide family support based on their needs and to clarify the mechanisms leading to dysfunctional family dynamics during the critical ARMS period

Ecological validity of expressed emotion in early psychosis

Expressed emotion (EE) is an aspect of the family environment that influences the course of multiple forms of psychopathology. However, there is limited research about how EE dimensions [i.e., criticism and emotional over-involvement (EOI)] are expressed in real-world settings. The present study used experience sampling methodology to investigate: 1) the criterion and construct validity of daily-life, momentary measures of criticism and EOI, and 2) the construct and ecological validity of psychometric EE-dimensions as assessed with the self-report Family Questionnaire (FQ). A total sample of 55 relatives (34 relatives of at-risk mental state patients and 21 of first-episode psychosis patients) were prompted randomly six times daily for 1-week to assess their current emotional experiences and cognitive appraisals. Relatives also completed the FQ. Momentary criticism and EOI were significantly associated with the two FQ-EE dimensions respectively, supporting the criterion validity of real-world assessed EE dimensions. As hypothesized, momentary and FQ-EE dimensions were associated with decreased positive affect, as well as with appraisals of less effective coping in daily life. Only momentary EE dimensions were associated with increased momentary negative affect. Partly in contrast with our hypotheses, momentary criticism and FQ-criticism were more consistently related to situational stress and burden than momentary EOI and FQ-EOI. Finally, neither momentary nor FQ-EE dimensions showed distinct patterns of associations with illness attributions. Findings partly support the construct validity of momentary criticism and EOI as well as the construct and ecological validity of the FQ as a sensitive measure of EE dimensions

Analysis and Optimization of Multi-Winding Toroidal Inductors for Use in Multilayered Technologies

The aim of this paper is to compare the performance of planar toroidal inductors and circular spiral inductors in multilayered technologies, in terms of achievable inductance density. New multi-winding toroidal inductor geometry is proposed to cover as much of the integration area as possible with the component footprint. The optimization of planar multi-winding toroidal inductors in multilayered substrates is investigated theoretically, and closed formulae are derived for their inductances as a function of geometrical parameters for any given value of the number of windings in the coil. The model obtained is validated experimentally and through electromagnetic simulation. Comparing the inductance of multi-winding toroidal inductors and compact spiral inductors allows us to update previously reported selection rules for the most suitable topology that leads to the most compact design

Assessment of 3D Printing Technologies for Millimeter Wave Reflectors

Three different 3D printing technologies: Stereolithography (SLA), Fused Deposition Modeling (FDM) and HP Multi Jet Fusion Technology (MJF) are compared to build a parabolic reflector operating at 100 GHz. Fabrication tolerance and surface roughness before and after metallization are accurately measured. The performance of the reflectors is measured in the near field and its performance is compared against an optical grade reflector. In this way the performance of the final product is thoroughly assesse

Wireless Biodevices and Systems - eHealth Platform Based on Arduino

Documentació associada a 3 sessions docents on es desenvolopa una plataforma eHealth basada en Arduino

Relatives' attachment anxiety mediates the association between perceived loss and expressed emotion in early psychosis

A common reaction experienced by family members of patients with psychosis is grief for the loss of their healthy relative. Importantly, high levels of perceived loss have been related to the manifestation of high expressed emotion (EE), which includes the negative attitudes expressed by relatives toward an ill family member. However, the mechanisms underlying the relationship between relatives' perceived loss and EE attitudes in the early stages of psychosis are still not fully understood. In this regard, attachment theory has been suggested as a useful framework for understanding this link. The current study aimed to examine: (1) whether relatives' perceived loss was associated with relatives' EE dimensions (i.e., criticism and emotional over-involvement (EOI)), and (2) whether such associations were mediated by relatives' attachment dimensions (i.e., anxiety and avoidance). Seventy-eight relatives of patients with early psychosis completed the Mental Illness Version of the Texas Inventory of Grief for the assessment of loss reactions. Attachment dimensions and EE attitudes were assessed by the Psychosis Attachment Measure and the Family Questionnaire, respectively. Findings indicated that relatives' perceived loss was associated with EE dimensions. Relatives' attachment anxiety, but not avoidance, mediated the relationship of perceived loss with both criticism and EOI. Findings highlight the importance of examining the role of relatives' attachment characteristics for understanding how perceptions of loss might impact the manifestation of EE attitudes in the early stages of psychosis. Family interventions aimed at assisting relatives to improve their management of negative emotional reactions to loss are fundamental to prevent impairing loss reactions and the entrenchment of high-EE attitudes

Multilayered broadband antenna for compact embedded implantable medical devices: design and characterization

Design and characterization of a multilayered compact implantable broadband antenna for wireless biotelemetry applications is presented in this paper. The main features of this novel design are miniaturized size, structure that allows integration of electronic circuits of the implantable medical device inside the antenna, and enhanced bandwidth that mitigates possible frequency detuning caused by heterogeneity of biological tissues. Using electromagnetic simulations based on the finite-difference timedomain method, the antenna geometry was optimized to operate in the 401-406 MHz Medical Device Radio communications service band. The proposed design was simulated implanted in a muscle tissue cuboid phantom and implanted in the arm, head, and chest of a high-resolution whole-body anatomical numerical model of an adult human male. The antenna was fabricated using low-temperature co-fired ceramic technology. Measurements validated simulation results for the antenna implanted in muscle tissue cuboid phantom. The proposed compact antenna, with dimensions of 14 mm × 16 mm × 2 mm, presented a −10 dB bandwidth of 103 MHz and 92 MHz for simulations and measurements, respectively. The proposed antenna allows integration of electronic circuit up to 10 mm × 10 mm × 0.5 mm. Specific absorption rate distributions, antenna input power, radiation pattern and the transmission channel between the proposed antenna and a half-wavelength dipole were evaluated

SuperB: A High-Luminosity Heavy Flavour Factory. Conceptual Design Report.

479 páginas.-- INFN/AE - 07/2, SLAC-R-856, LAL 07-15.-- et al.Work supported in part by US department of Energy contract DE-AC02-7 6SF00515. SuperB project.Peer reviewe

The transcriptional co-activator PCAF regulates cdk2 activity

Cyclin dependent kinases (cdks) regulate cell cycle progression and transcription. We report here that the transcriptional co-activator PCAF directly interacts with cdk2. This interaction is mainly produced during S and G2/M phases of the cell cycle. As a consequence of this association, PCAF inhibits the activity of cyclin/cdk2 complexes. This effect is specific for cdk2 because PCAF does not inhibit either cyclin D3/cdk6 or cyclin B/cdk1 activities. The inhibition is neither competitive with ATP, nor with the substrate histone H1 suggesting that somehow PCAF disturbs cyclin/cdk2 complexes. We also demonstrate that overexpression of PCAF in the cells inhibits cdk2 activity and arrests cell cycle progression at S and G2/M. This blockade is dependent on cdk2 because it is rescued by the simultaneous overexpression of this kinase. Moreover, we also observed that PCAF acetylates cdk2 at lysine 33. As this lysine is essential for the interaction with ATP, acetylation of this residue inhibits cdk2 activity. Thus, we report here that PCAF inhibits cyclin/cdk2 activity by two different mechanisms: (i) by somehow affecting cyclin/cdk2 interaction and (ii) by acetylating K33 at the catalytic pocket of cdk2. These findings identify a previously unknown mechanism that regulates cdk2 activity